Fig. 5

Network topology-based analysis using the PPI BioGRID network for expansion. A Construction of top 10 enriched gene ontology biological process terms. B Sub-network graph obtained from enrichment analysis. Gene ontology enrichment analysis of biological process terms is visualized as a dendrogram with the ten significantly enriched terms highlighted in red. The ancestors of these enriched terms are shown in light yellow. The sub-network graph contains five seeds (S100A8, S100A9, HNRNPDL, SRSF5, HNRNPUL1), among which calprotectin proteins (S100A8 and S100A9) are presented as neighbor seeds that are highlighted in all ten enriched GO terms