A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene

Roy, Arpita Singha; Feroz, Tasmiah; Islam, Md. Kobirul; Munim, Md. Adnan; Supti, Dilara Akhter; Antora, Nusrat Jahan; Al Reza, Hasan; Gosh, Supriya; Bahadur, Newaz Mohammed; Alam, Mohammad Rahanur; Hossain, Md Shahadat

doi:10.1186/s44342-024-00007-2

Table 1 List of highly deleterious nsSNPs screened by seven computational programs

From: A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene

	PANTHER	PROVEAN	PredictSNP	PolyPhen-2	PhD-SNP	PON-P2	SIFT
V478A	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
R489H	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
L610F	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
I644T	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
L648R	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
P698T	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
P698S	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
P698L	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
E747G	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
L781P	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
H827P	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
H827R	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
R830K	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
V864F	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
I867K	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
I867R	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
H871Q	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious
R894W	Probably damaging	Deleterious	Deleterious	Probably damaging	Disease	Pathogenic	Deleterious

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ISSN: 2234-0742

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