Fig. 3
From: Structural insights into antibody-based immunotherapy for hepatocellular carcinoma
Binding mechanism of PD-L1 inhibiting monoclonal antibodies (mAbs). A PD-L1 binding mAbs are superimposed on a single PD-1 molecule, with corresponding PDB IDs listed in Table 1. PD-1 binding basic residues R113 and K124 are shown in as red surfaces. B Alignment of the complementarity-determining regions (CDRs) from the mAbs presented in panel A. C Superimposition of PD-L1 binding mAbs, constructed using AlphaFold 3. D Alignment of the CDRs from the mAbs depicted in panel C