Table 1 Functional impact of SOD1 missense mutations predicted using PROVEAN, PolyPhen-2, PhD-SNP and Meta-SNP
Mutants | PROVEAN | PolyPhen-2 | PhD-SNP | Meta- SNP | ||||
|---|---|---|---|---|---|---|---|---|
Score | Interpretation | Score | Interpretation | Score | Interpretation | Score | Interpretation | |
Cys6Gly |  − 9.492 | Deleterious | 1.0 | Probably damaging | 0.803 | Disease-causing | 0.673 | Disease causing |
Cys6Phe |  − 8.793 | 1.0 | 0.807 | 0.652 | ||||
Cys6Ser |  − 7.878 | 1.0 | 0.694 | 0.554 | ||||
Cys6Trp |  − 8.818 | 1.0 | 0.839 | 0.730 | ||||