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Table 2 Changes in intramolecular interactions in SOD1 protein due to mutations

From: Impact of cysteine mutations on the structural dynamics and functional impairment of SOD1: insights into the pathogenicity of amyotrophic lateral sclerosis

Interaction

Cys6 WT

Cys6Trp

Cys6Phe

Cys6Ser

Cys6Gly

Polar

Leu117, Ile18

Ile18

Ile18

Val148, Ile18

1le18

Hydrophobic

Ile149, Phe20, Leu117

Ile18, Val47, Ile112, Leu117, Phe20, Ile149

Ile149, Leu117, Leu8, Cys146

  

VDW

Gly147

Leu117, Ile112, Ile149, Gly150

Val148, Leu8

-

 

H bond

Ile18

Ile18

-

-

 
  1. Key: VDW van der Waals interactions.
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Genomics & Informatics

ISSN: 2234-0742

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